paclitaxelloaded dqasomes uj day after tumor implantation fig tumor growth inhibition study in nude mice implanted with human colon cancer cells the keflex rubber expansion joints mean tumor volume from each group was blotted against the number of keflex rubber expansion joints days each group involved animals for clarity, error bars were omitted note that after weeks the dose, normalized for risperdal decreasing use paclitaxel, was tripled in all treatment groups empty dqasomes do not show any impact on tumor growth, keflex rubber expansion joints paclitaxelloaded dqasomes with paclitaxel and dequalinium keflex rubber expansion joints concentrations identical to controls seem to inhibit the tumor growth by about keflex rubber expansion joints correspondingly, the average tumor weight in keflex rubber expansion joints the treatment group, after sacrificing the animals days, later was approximately half of that in all controls although this result seems to suggest that dqasomes might indeed be able to increase the therapeutic potential of keflex rubber expansion joints paclitaxel, the preliminary character of this first in vivo study has to be emphasized experiments to optimize the treatment protocol are ongoing in the authors laboratory summary since their initial keflex rubber expansion joints description in , dqasomes and dqasomelike vesicles have been established as the first mitochondriatargeted colloidal delivery system, capable of transporting plasmid dna as well as small drug molecules towards mitochondria within keflex rubber expansion joints living mammalian cells the further exploration of this unique mitochondriotropic delivery system will introduce new ways for the treatment of cancer and for keflex rubber expansion joints the therapy of a multitude of keflex rubber expansion joints mitochondrial diseases acknowledgments i am grateful to prof v p torchilin for many helpful discussions and for his strong and continuous support of my work i also would like to sincerely thank my graduate students, gerard dsouza, shingming cheng, sarathi boddapati and eyad katrangi, whose experimental work has made the writing of this chapter possible i am obliged to the muscular dystrophy association tucson, az, the united mitochondrial disease foundation pittsburgh, pa, mitovec, inc boston, ma and northeastern university boston, ma for the keflex rubber expansion joints financial support i received from these organizations during the last four years references weissig v, lasch j, erdos g, meyer hw, rowe tc and hughes j dqasomes a novel potential drug and gene delivery system made from dequalinium pharm res � smith ra, porteous cm, gane am and keflex rubber expansion joints murphy mp delivery of bioactive molecules keflex rubber expansion joints to mitochondria in vivo proc natl acad sci usa murphy mp and keflex rubber expansion joints smith ra drug delivery to mitochondria the key to mitochondrial medicine adv drug del rev muratovska a, lightowlers rn, taylor rw, wilce ia and murphy mp targeting large molecules to mitochondria adv drug del rev szewczyk a and wojtczak l mitochondria as a pharmacological target pharmacol rev weissig v mitochondrialtargeted drug and dna keflex rubber expansion joints delivery crit rev ther drug carr syst weissig v, cheng sm and dsouza g mitochondrial pharmaceutics mitochondrion weissig v targeted drug delivery to mammalian keflex rubber expansion joints mitochondria in living cells exp opin drug del weissig v, boddapati sv, dsouza ggm and cheng sm targeting keflex rubber expansion joints of low molecular weight drugs to mammalian mitochondria drug des rev de keflex rubber expansion joints rosa m, gambacorta a and gliozi a structure, biosynthesis, and physico chemical properties of archaebacterial lipids microbiol rev keflex rubber expansion joints gambacorta a, gliozi a and keflex rubber expansion joints de rosa m archaeal lipids and their biotechnological applications world j microbiol biotechnol weissig v, mogel hj, wahab m and lasch j computer simulations of dqasomes proc intl symp control rel bioact mater weissig v, lizano keflex rubber expansion joints � and torchilin vp a micellar keflex rubber expansion joints delivery system for dequalinium � a keflex rubber expansion joints lipophilic cationic drug with anticarcinoma activity j lipos res weissig v, lizano c, ganellin cr and torchilin vp keflex rubber expansion joints dna binding cationic bolasomes with delocalized charge center a structureactivity relationship study keflex rubber expansion joints stp pharma sci chrzanowskalightowlers zm, lightowlers rn and turnbull dm gene therapy keflex rubber expansion joints for mitochondrial dna defects is it possible?